Androstenedione: The Banned Supplement and Its Side Effects

Androstenedione, commonly known as “andro,” was once a popular dietary supplement touted for its ability to enhance athletic performance, stimulate muscle growth, and boost testosterone levels. However, this supplement has since been banned due to its serious health risks. In this comprehensive article, we will delve into the various side effects of androstenedione, its legal status, historical uses, alternative supplements, and safety concerns.

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Androstenedione: The Banned Supplement

What is Androstenedione?

Androstenedione is a naturally occurring steroid hormone that plays a crucial role in the production of testosterone and estrogen in both men and women. It is primarily produced in the adrenal glands and gonads. Historically, androstenedione was extracted from animal sources and used as a treatment for certain medical conditions. However, due to its potential for abuse and health risks, its use as a dietary supplement has been banned in many countries.

Side Effects of Androstenedione

A. Effects on Men

  1. Testicular Atrophy: Prolonged use of androstenedione can lead to the shrinkage of the testicles, which may result in reduced fertility and testosterone production.
  2. Impotence: Androstenedione abuse can disrupt normal hormonal balance and contribute to erectile dysfunction and decreased sexual function.
  3. Development of Female Characteristics: Excessive androstenedione intake can cause the development of feminine traits in men, such as breast enlargement and decreased body hair growth.

B. Effects on Women

  1. Male Characteristics: Androstenedione use in women can lead to the development of masculine characteristics, including deepening of the voice, facial hair growth, and male-pattern baldness.
  2. Abnormal Menstrual Cycles and Bleeding: Androstenedione can disrupt the normal hormonal balance in women, leading to irregular menstrual cycles and increased risk of excessive bleeding.
  3. Increased Risk of Breast and Endometrial Cancer: Prolonged androstenedione use has been associated with an increased risk of hormone-related cancers such as breast and endometrial cancer in women.

C. Effects on Children and Teens

  1. Hormonal Effects: Androstenedione abuse among children and teenagers can disrupt normal hormonal development, leading to imbalances and potential long-term health consequences.
  2. Early Onset of Puberty: Excessive androstenedione intake in adolescents can accelerate the onset of puberty, potentially causing developmental and emotional challenges.
  3. Premature Cessation of Growth: Androstenedione abuse can lead to premature closure of growth plates, resulting in stunted height and compromised skeletal development.

D. Cardiovascular Risks

  1. Heart and Blood Vessel Damage: Androstenedione has been associated with an increased risk of cardiovascular problems, including hypertension, atherosclerosis, and damage to the heart and blood vessels.
  2. Increased Risk of Heart Attacks and Strokes: Prolonged use of androstenedione can elevate the risk of heart attacks and strokes, especially in individuals with pre-existing cardiovascular conditions.

E. Drug Interactions

  1. Interactions with Medications: Androstenedione can interact with certain medications, including blood thinners and anti-inflammatory drugs, potentially leading to adverse effects and compromised therapeutic outcomes.
  2. Effects on Androstenedione Concentrations: Some medications can alter the metabolism and clearance of androstenedione, affecting its concentrations in the body and leading to unpredictable effects.

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Alternative Supplements Sold as “Andro”

A. 1-Andro

  1. Chemical Structure and Effects: 1-Andro, also known as 1-DHEA, is a legal alternative to androstenedione. It is a prohormone that converts to 1-testosterone in the body. This conversion is believed to contribute to increased muscle mass, strength, and performance.
  2. Safety Profile: While 1-Andro is marketed as a safer alternative to androstenedione, it still carries potential risks. Users may experience side effects such as acne, hair loss, and liver toxicity. Long-term effects and safety data on 1-Andro are limited, and its use should be approached with caution.

B. DHEA (Dehydroepiandrosterone)

  1. Introduction: DHEA is a naturally occurring hormone produced by the adrenal glands. It is involved in the production of testosterone and estrogen. DHEA supplements are sometimes marketed as alternatives to androstenedione.
  2. Effects and Safety: DHEA supplementation has been linked to potential benefits such as improved mood, energy levels, and muscle strength. However, its long-term effects and safety profile are not fully understood. DHEA can also have hormonal effects and may lead to imbalances in some individuals.

Legal Status of Androstenedione

Androstenedione has been classified as a controlled substance and is banned for over-the-counter sale in several countries, including the United States. It is listed as a prohibited substance by sports organizations such as the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA). The ban on androstenedione is a result of its potential health risks and performance-enhancing properties.

Historical Uses and Controversies

A. Historical Uses

  1. Medical Applications: Androstenedione was initially used in medical settings to treat conditions such as low testosterone levels and certain hormonal disorders. However, its use was later discontinued due to the availability of safer and more effective alternatives.
  2. Athletic Performance: Androstenedione gained popularity in the 1990s as a performance-enhancing supplement after it was reported that professional athletes, including baseball players, were using it to improve their performance and muscle mass.

B. Controversies

  1. Efficacy as a Performance Enhancer: The effectiveness of androstenedione in enhancing athletic performance remains a subject of debate. Some studies have shown minimal benefits, while others have highlighted potential risks and limited evidence of significant performance improvement.
  2. Misleading Marketing and Labeling: The marketing of androstenedione as a safe and effective dietary supplement without clearly highlighting its potential risks contributed to its widespread use and subsequent ban.

Safety Concerns and Recommendations

A. Education and Awareness

  1. Public Education: It is essential to raise awareness about the potential dangers of androstenedione abuse, especially among athletes, bodybuilders, and individuals seeking performance enhancement.
  2. Reliable Information Sources: Encouraging individuals to seek information from reputable sources, such as healthcare professionals and organizations dedicated to sports medicine and nutrition, can help prevent the misuse of androstenedione and promote informed decision-making.

B. Regulation and Enforcement

  1. Strengthened Regulations: Governments and regulatory authorities should establish and enforce stricter regulations on the manufacturing, labeling, and sale of dietary supplements to ensure consumer safety.
  2. Monitoring and Testing: Implementing regular monitoring and testing programs in sports organizations and ensuring stringent anti-doping measures can deter the use of banned substances like androstenedione.

Also Read: What You Need to Know About Dietary Supplements: Benefits, Risks, and How to Choose the Right One

C. Alternative Approaches

  1. Natural Methods: Emphasizing the importance of proper nutrition, regular exercise, and adequate rest as the foundation for achieving optimal athletic performance. Natural approaches focus on balanced diets rich in lean proteins, healthy fats, and carbohydrates, along with appropriate training protocols.
  2. Legal Supplements: Encouraging the use of legal and safe dietary supplements that have undergone rigorous testing and have a proven track record of efficacy. It is crucial to consult with healthcare professionals or certified sports nutritionists to identify suitable alternatives based on individual needs and goals.

D. Focus on Long-Term Health

  1. Sustainable Practices: Shifting the focus from short-term gains to long-term health and well-being. Prioritizing overall health and fitness goals rather than relying solely on performance-enhancing substances can help prevent the temptation to use banned substances like androstenedione.
  2. Holistic Approaches: Adopting holistic approaches that include mental well-being, stress management, and injury prevention as integral components of athletic performance. This comprehensive approach promotes longevity in sports and reduces the reliance on potentially harmful substances.


Androstenedione, once popular as a dietary supplement for its purported muscle-building and performance-enhancing effects, has been banned due to its significant health risks. The side effects of androstenedione range from hormonal imbalances and reproductive issues to increased cardiovascular risks. Understanding the dangers associated with androstenedione is crucial for athletes, bodybuilders, and individuals seeking to optimize their physical performance.

While alternative supplements like 1-Andro and DHEA are available, they too come with potential risks and limited evidence of their long-term safety. Prioritizing natural methods, including proper nutrition, regular exercise, and rest, along with legal and scientifically supported supplements, can help individuals achieve their performance goals without compromising their health.

Education, regulation, and awareness play key roles in mitigating the misuse of androstenedione. By promoting accurate information, strengthening regulations, and implementing monitoring and testing programs, we can discourage the use of banned substances and prioritize the well-being and long-term health of athletes and fitness enthusiasts.

Remember, the pursuit of athletic excellence should always prioritize health and safety, and the use of banned substances like androstenedione is not worth the potential risks it poses. By adopting sustainable and holistic approaches to training, athletes can optimize their performance while maintaining their overall well-being.

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